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Cancel Order? Because of Corona Virus Fallout?

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Old 06-07-2020, 05:59 PM
  #271  
S4to911
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Originally Posted by Metalblond
Like I said, I'm not sure if it helped but he is alive and well now. He was one of the earlier diagnoses and he was doing so poorly they agreed to try everything that they could.
I know a few people who have had to take HCQ due to travel and malaria--one very long term. It is scary to think that the people who really need it cannot get it because of people stockpiling-- but that seems to be true with everything now, unfortunately.
No worries on that front. HCQ has a half life of weeks. People on it long term for SLE or RA can be without it for about 1-2 months they have so much on board.
Old 06-07-2020, 06:03 PM
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Originally Posted by rk-d
HCQ or not, it's great to hear about a recovery.

That said, the data just isn't there. I don't write it for my patients with COVID19 and I would not give it to my family. Meanwhile, the patients who actually need this drug have struggled to get it and are subjected to delayed refills from prior authorization demands and rationed supplies.
The rationing issue, just like the QT stuff, is a dead straw man. HCQ half life is long and you can go about a month or longer without it. Do you personally know anyone who flared their SLE since they didnt get it? There is plenty nationally to go around anyway since the pandemic is waning. Anyone talking about the most recent Ct values on viral PCR? There is less viral load in the more recent ones. You know what that means, right?
Old 06-07-2020, 06:04 PM
  #273  
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Originally Posted by Manoverpdk
Seems many inbound vehicles or orders have been orphaned, including the Spyders and GT4s.
I know a guy in Pittsburgh waiting for his Genitian Blue Spyder.
Old 06-07-2020, 06:05 PM
  #274  
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Originally Posted by sechsgang
Well, hey, that's beyond awesome!
There is a trial of famotidine at Northwell Hospital in LI.
Old 06-07-2020, 06:06 PM
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Originally Posted by rk-d
I am hearing and seeing the same. A possible decline in potency. No one wants to say it out loud.

Ironically, immunosuppression (at least with biologics) doesn't seem to result in worse outcomes. Given the pathophysiology, it probably makes sense. If you pull the fuse, the bomb doesn't go off.
The science behind all of this is really cool, btw.
Old 06-07-2020, 06:08 PM
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Originally Posted by AKSteve
Kind of. As times goes on, it seems more and more like this virus isn't the deadly killer we first thought that it was. Having said that, it does still kill people. And the Pepcid idea was started from some info that was based on a New York doctor who travelled to China and noticed that the lower income Covid-19 patients were doing better than the well-off patients. After doing some digging, they found out that the lower income patients who were doing well were also taking the cheapest antacid available, which was Pepcid. Sounds goofy, but there may or may not be something to it.

The Department of Defense currently has a $20million research program that is looking into this. And after doing some digging around, I was able to come up with this info about why it may work: "a pharmacological profiling group working for the Pentagon identified the drug as a compound capable of binding to a distinctive coronavirus enzyme, potentially allowing it to disrupt the virus’ action."

All I know is I bought some and I've been taking it...because, why not? It really can't do any harm and it may very well help. I have also been taking chelated zinc and vitamin D.
That $20 million DOD program has the mechanism of famotidine wrong btw. Oh well.
Old 06-07-2020, 06:09 PM
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Originally Posted by AKSteve
I personally like toculizumab better.
Old 06-07-2020, 06:11 PM
  #278  
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Originally Posted by S4to911
The rationing issue, just like the QT stuff, is a dead straw man. HCQ half life is long and you can go about a month or longer without it. Do you personally know anyone who flared their SLE since they didnt get it? There is plenty nationally to go around anyway since the pandemic is waning. Anyone talking about the most recent Ct values on viral PCR? There is less viral load in the more recent ones. You know what that means, right?
Nice attitude. Yes, I have patients with lupus who have flared because they've run out of HCQ that was unavailable, rationed or denied. This is what I do for a living. Spare me the snide bulls*t, by the way. I'm not impressed.

Old 06-07-2020, 06:15 PM
  #279  
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Originally Posted by rk-d
HCQ continues to be pushed pretty aggressively in India for healthcare worker prophylaxis. The big Lancet study was redacted due to the Surgisphere fiasco, but other trials including a recent 4600 person RCT have failed to show efficacy.

Nonetheless, there are a slew of repurposed drugs and interventions that show real promise. I am cautiously optimistic that we'll have meaningful options this fall.
The 4600 patient UK RECOVERY study had a second randomization to toculizumide or not in the control if CRP > 75. HCQ lowers inflammatory markers like CRP, no toci likely not given, since CRP likely less than 75 in a lot of HCQ treated patients. We need to see that data before making any broad declarations.

That being said, it’s not just about HCQ. It’s about a theory of disease that explains that a lot of stuff may work. Obviously we need to do the trials as we are doing. The point is that the physicians and scientists are on it, and there is hope.
Old 06-07-2020, 06:16 PM
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Originally Posted by rk-d
Nice attitude. Yes, I have patients with lupus who have flared because they've run out of HCQ that was unavailable, rationed or denied. This is what I do for a living. Spare me the snide bulls*t, by the way. I'm not impressed.
Not being snide, just honestly curious. You are a rheumatologist I take it? What part of the country do you live in?
Old 06-07-2020, 06:18 PM
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Originally Posted by rk-d
Nice attitude. Yes, I have patients with lupus who have flared because they've run out of HCQ that was unavailable, rationed or denied. This is what I do for a living. Spare me the snide bulls*t, by the way. I'm not impressed.
As I said from the beginning don’t attack me, attack the ideas. Let’s have a reasoned discussion.
Old 06-07-2020, 06:20 PM
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Originally Posted by S4to911
Not being snide, just honestly curious. You are a rheumatologist I take it? What part of the country do you live in?
i say this because a lot of us have been keeping close tabs on the HCQ supply, and reports like yours need to be dealt with.
Old 06-07-2020, 06:24 PM
  #283  
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Number 1 rule: never run away from fear.
If you are able to function under fear, distress, panic: you made it

Back to subject, do not cancel any order due to corona. Live your life. We are going to die one day, that's guaranteed.
So enjoy and life. We have enough time to worry after death.
The following 4 users liked this post by uniqueMR:
kwikit356 (06-07-2020), Manoverpdk (06-08-2020), markchristenson (06-07-2020), Metalblond (06-07-2020)
Old 06-07-2020, 06:35 PM
  #284  
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Originally Posted by S4to911
There is a trial of famotidine at Northwell Hospital in LI.
I’ve been taking it for almost a month now along with chelated zinc and vitamin A/D. I don’t know if this stuff would help me at all if I were to I get exposed to the virus, but at least I feel like I’m taking a few things that might help. And it can’t really hurt.
Old 06-07-2020, 06:37 PM
  #285  
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Originally Posted by S4to911
As I said from the beginning don’t attack me, attack the ideas. Let’s have a reasoned discussion.
Also, please accept my apologies for appearing snide. I am honestly curious since I have heard scattered reports like yours but have not seen any widespread shortages of HCQ for lupus. In my business (I’m not a rheum doc) my few patients on HCQ have been able to get it.


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