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Search: Posts Made By: S4to911
Showing results 1 to 25 of 181
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Forum: 992
06-09-2020, 12:36 PM
Replies: 335
Views: 50,860
Posted By S4to911

Don’t have a lot of time to talk, but think if it...

Don’t have a lot of time to talk, but think if it this way. There is a very controversial theory floating around that hypertension is really an inflammatory disease in the end. There just may be...
Forum: 992
06-08-2020, 02:00 AM
Replies: 335
Views: 50,860
Posted By S4to911

I saw that. My guess is that biologics control...

I saw that. My guess is that biologics control mortality, not necessarily infection.

Though there are these two trials:

Pre-exposiure prophylaxis in India ...
Forum: 992
06-08-2020, 01:55 AM
Replies: 335
Views: 50,860
Posted By S4to911

Let's not go there with this trial. It's an...

Let's not go there with this trial. It's an observational trial that did not control for FiO2 <300, which is a measure of illness. Median FiO2 in the HCQ arm was 226; in the control around 325. The...
Forum: 992
06-07-2020, 08:06 PM
Replies: 335
Views: 50,860
Posted By S4to911

Forgot this reference. HCQ drops IL-6 in this...

Forgot this reference. HCQ drops IL-6 in this study. https://www.medrxiv.org/content/10.1101/2020.04.27.20073379v1

Also, there are much cheaper markers of cytokine storm and death than IL-6....
Forum: 992
06-07-2020, 08:03 PM
Replies: 335
Views: 50,860
Posted By S4to911

Seems to be type II. Hyperglycemia is a risk...

Seems to be type II. Hyperglycemia is a risk factor for COVID and control of it can decrease mortality. Check this out.

https://www.sciencedirect.com/science/article/pii/S1550413120302382
Forum: 992
06-07-2020, 08:01 PM
Replies: 335
Views: 50,860
Posted By S4to911

I too am irritated by the whole HCQ mess. It...

I too am irritated by the whole HCQ mess. It either works for COVID or it doesn't. We test it in a well controlled RCT to find out one way or the other. There may be subgroups that benefit. It became...
Forum: 992
06-07-2020, 06:40 PM
Replies: 335
Views: 50,860
Posted By S4to911

It doesn’t hurt, and may work. Just be careful to...

It doesn’t hurt, and may work. Just be careful to not overdose on D. We cant give medical advice over the internet as you know.
Forum: 992
06-07-2020, 06:37 PM
Replies: 335
Views: 50,860
Posted By S4to911

Also, please accept my apologies for appearing...

Also, please accept my apologies for appearing snide. I am honestly curious since I have heard scattered reports like yours but have not seen any widespread shortages of HCQ for lupus. In my business...
Forum: 992
06-07-2020, 06:20 PM
Replies: 335
Views: 50,860
Posted By S4to911

i say this because a lot of us have been keeping...

i say this because a lot of us have been keeping close tabs on the HCQ supply, and reports like yours need to be dealt with.
Forum: 992
06-07-2020, 06:18 PM
Replies: 335
Views: 50,860
Posted By S4to911

As I said from the beginning don’t attack me,...

As I said from the beginning don’t attack me, attack the ideas. Let’s have a reasoned discussion.
Forum: 992
06-07-2020, 06:16 PM
Replies: 335
Views: 50,860
Posted By S4to911

Not being snide, just honestly curious. You are a...

Not being snide, just honestly curious. You are a rheumatologist I take it? What part of the country do you live in?
Forum: 992
06-07-2020, 06:15 PM
Replies: 335
Views: 50,860
Posted By S4to911

The 4600 patient UK RECOVERY study had a second...

The 4600 patient UK RECOVERY study had a second randomization to toculizumide or not in the control if CRP > 75. HCQ lowers inflammatory markers like CRP, no toci likely not given, since CRP likely...
Forum: 992
06-07-2020, 06:09 PM
Replies: 335
Views: 50,860
Posted By S4to911

I personally like toculizumab better.

I personally like toculizumab better.
Forum: 992
06-07-2020, 06:08 PM
Replies: 335
Views: 50,860
Posted By S4to911

That $20 million DOD program has the mechanism of...

That $20 million DOD program has the mechanism of famotidine wrong btw. Oh well.
Forum: 992
06-07-2020, 06:06 PM
Replies: 335
Views: 50,860
Posted By S4to911

The science behind all of this is really cool,...

The science behind all of this is really cool, btw.
Forum: 992
06-07-2020, 06:05 PM
Replies: 335
Views: 50,860
Posted By S4to911

There is a trial of famotidine at Northwell...

There is a trial of famotidine at Northwell Hospital in LI.
Forum: 992
06-07-2020, 06:04 PM
Replies: 335
Views: 50,860
Posted By S4to911

I know a guy in Pittsburgh waiting for his...

I know a guy in Pittsburgh waiting for his Genitian Blue Spyder.
Forum: 992
06-07-2020, 06:03 PM
Replies: 335
Views: 50,860
Posted By S4to911

The rationing issue, just like the QT stuff, is a...

The rationing issue, just like the QT stuff, is a dead straw man. HCQ half life is long and you can go about a month or longer without it. Do you personally know anyone who flared their SLE since...
Forum: 992
06-07-2020, 05:59 PM
Replies: 335
Views: 50,860
Posted By S4to911

No worries on that front. HCQ has a half life of...

No worries on that front. HCQ has a half life of weeks. People on it long term for SLE or RA can be without it for about 1-2 months they have so much on board.
Forum: 992
06-07-2020, 05:57 PM
Replies: 335
Views: 50,860
Posted By S4to911

As I said this isn’t amateur hour. When you make...

As I said this isn’t amateur hour. When you make a statement like that you need to back it up with data. Guys like me do trials like the HCQ ones for a living. If you have data to back up that...
Forum: 992
06-06-2020, 10:46 PM
Replies: 335
Views: 50,860
Posted By S4to911

The virus attacks a series of cells in the body....

The virus attacks a series of cells in the body. They are the pneumocytes of the lung, endothelial cells that line blood vessels of organs, and a master cells of the immune system called the...
Forum: 992
06-06-2020, 09:17 PM
Replies: 335
Views: 50,860
Posted By S4to911

Driving my 2020 992 4S Cab (got it right before...

Driving my 2020 992 4S Cab (got it right before they closed up PA on 3/16/20) for long rides is the only thing that kept me partially sane during the past 10 weeks of 15 hour days 7 days per week.
...
Forum: 992
06-06-2020, 09:14 PM
Replies: 335
Views: 50,860
Posted By S4to911

It’s been a while. We know what is going on with...

It’s been a while. We know what is going on with the coronavirus, if anyone wants to know. This is a Porsche forum so I’m not quite sure its appropriate. But if there is interest I can explain some...
Forum: 992
05-27-2020, 11:01 PM
Replies: 2,584
Views: 1,023,135
Posted By S4to911

https://cimg8.ibsrv.net/gimg/rennlist.com-vbulleti...

https://cimg8.ibsrv.net/gimg/rennlist.com-vbulletin/2000x1504/img_0376_834d3679b46ee9becb9cfca8bd0f6757ce4adbba.jpeg
Here is mine. Picked up on 3/15/20, right before PA was closed.
Forum: 992
03-26-2020, 08:06 PM
Replies: 335
Views: 50,860
Posted By S4to911

I hope everyone is doing well and is healthy,...

I hope everyone is doing well and is healthy, especially in hard hit areas. Based on the epidemic trajectory, even though this looks really bad right now, we are possibly at the peak in these areas....
Showing results 1 to 25 of 181
 
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